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Available Strengths
Duloxetine is available in different strengths to meet the individual needs of patients. The available strengths of Duloxetine include 20 mg, 30 mg, 40 mg, and 60 mg capsules. This variety allows healthcare providers to choose the most appropriate strength based on the patient’s specific condition and response to treatment.
Recommended Dosage
It is important to follow your healthcare provider’s instructions when taking Duloxetine. The recommended dosage for adults with major depressive disorder is typically 60 mg once daily; however, your doctor may adjust the dosage based on your individual needs. It is usually recommended to take Duloxetine at the same time each day, with or without food.
Special Populations
- For patients with kidney impairment: Dosage adjustments may be necessary based on the severity of renal impairment. Consult your healthcare provider for appropriate dosing recommendations.
- For patients with liver impairment: Dosage adjustments may be required for individuals with hepatic dysfunction. Your doctor will determine the appropriate dose for you based on your liver function.
Do not suddenly stop taking Duloxetine without consulting your healthcare provider, as this can lead to withdrawal symptoms. If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule.
Recommended Dosage
When prescribing Duloxetine, healthcare providers should consider the individual patient’s needs and the condition being treated. The recommended starting dose for most adults with major depressive disorder is 40 mg once daily. Based on individual patient response, the dose may be increased to a maximum of 60 mg per day.
For generalized anxiety disorder, the recommended starting dose is 30 mg once daily, with a potential increase to 60 mg once a day if needed. For the management of diabetic peripheral neuropathic pain, the usual starting dose is 60 mg once daily, with a maximum dose of 120 mg per day.
| Indication | Starting Dose | Maximum Dose |
|---|---|---|
| Major Depressive Disorder | 40 mg/day | 60 mg/day |
| Generalized Anxiety Disorder | 30 mg/day | 60 mg/day |
| Diabetic Peripheral Neuropathic Pain | 60 mg/day | 120 mg/day |
It is important for patients to follow the prescribed dosage and consult their healthcare provider for any dose adjustments or concerns about side effects.
Potential Side Effects
Common side effects:
- Nausea: Some patients may experience nausea as a side effect of taking Duloxetine.
- Headache: Headaches are a common side effect that may occur during treatment with Duloxetine.
Less common side effects:
- Insomnia: Difficulty sleeping may occur in some individuals taking Duloxetine.
- Dizziness: Some patients may experience dizziness as a side effect of Duloxetine.
Severe side effects (rare but serious):
- Suicidal thoughts: In rare cases, Duloxetine may cause suicidal thoughts, especially in young adults.
- Serotonin syndrome: An extreme reaction that can be life-threatening, characterized by agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, and diarrhea.