Duloxetine material safety data sheet

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Attention: Please read this Material Safety Data Sheet (MSDS) carefully before using duloxetine.

Duloxetine is a prescription medication used to treat depression, anxiety, and certain types of chronic pain. It is important to understand the safety guidelines and precautions when handling this medication.

Precautions: Use gloves when handling duloxetine to avoid skin contact. Keep the medication out of reach of children and pets. Store duloxetine in a cool, dry place away from direct sunlight.

Emergency Contact: In case of accidental ingestion or exposure, contact a poison control center or seek medical help immediately.

For more information on the safe use of duloxetine, refer to the complete Material Safety Data Sheet provided by your healthcare provider.

Overview of Duloxetine

Duloxetine is a medication used to treat depression, anxiety, and certain types of chronic pain. It belongs to a class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). Duloxetine works by increasing the levels of serotonin and norepinephrine in the brain, which are neurotransmitters that play a role in regulating mood and pain perception.

It is commonly prescribed to adults for the treatment of major depressive disorder, generalized anxiety disorder, diabetic neuropathy, fibromyalgia, and chronic musculoskeletal pain. Duloxetine comes in various strengths and formulations including capsules, delayed-release capsules, and oral solutions.

It is important to follow the prescribed dosage and instructions provided by your healthcare provider when taking duloxetine to ensure its effectiveness and minimize the risk of side effects. Common side effects of duloxetine may include nausea, dry mouth, dizziness, drowsiness, and fatigue.

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If you experience any severe or persistent side effects while taking duloxetine, it is important to consult your healthcare provider immediately. Do not discontinue the medication without professional guidance as abrupt discontinuation may lead to withdrawal symptoms.

Overview of Duloxetine

Duloxetine, also known by the brand name Cymbalta, is a medication used to treat depression, anxiety, and certain types of chronic pain. It belongs to a class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of neurotransmitters in the brain.

How Duloxetine Works:

Duloxetine works by blocking the reabsorption of serotonin and norepinephrine in the brain, which can help improve mood and reduce pain signals. It is believed to enhance the communication between nerve cells and regulate emotions.

Available Forms:

Duloxetine is available in capsule form for oral administration. The capsules come in various strengths to allow for dosing flexibility based on individual needs.

Common Side Effects:

Common side effects of duloxetine may include nausea, dry mouth, dizziness, fatigue, and constipation. It is important to discuss any side effects with your healthcare provider.

Physical and Chemical Properties

Below is a table summarizing the physical and chemical properties of Duloxetine:

Property Value
Appearance White to off-white solid
Odor Odorless
Molecular Formula C18H19NOS
Molecular Weight 279.4 g/mol
Solubility Soluble in water
pKa 9.9 (at 25°C)

These properties are important to understand the behavior and characteristics of Duloxetine in various environments.

Hazards Identification

Hazards Identification

When handling duloxetine, it is essential to be aware of potential hazards associated with the substance. Duloxetine may cause skin irritation upon contact. In case of exposure, avoid direct skin contact and ensure the use of appropriate protective equipment, such as gloves and goggles.

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Inhalation of duloxetine dust or vapors should be avoided, as it may cause respiratory irritation. Ensure proper ventilation in the working area to reduce the risk of inhalation exposure. If respiratory symptoms occur, move to a well-ventilated area and seek medical attention.

Duloxetine may also pose a risk of eye irritation. In case of eye contact, rinse thoroughly with water for at least 15 minutes, while holding eyelids open. Seek medical advice if irritation persists.

It is important to store duloxetine in a dry, well-ventilated area away from incompatible substances. Ensure proper labeling and segregation to prevent accidental exposure. In case of spills or leaks, follow appropriate cleanup procedures and wear protective equipment.

By understanding the hazards associated with duloxetine and implementing proper safety measures, the risks of exposure can be minimized, ensuring a safe working environment for all personnel.

First Aid Measures

In case of contact with eyes, immediately flush with plenty of water for at least 15 minutes. Ensure to remove contact lenses if present and continue rinsing. Seek medical attention if irritation persists.

Skin Contact:

If skin contact occurs, remove contaminated clothing and wash the affected area thoroughly with soap and water. If irritation develops, seek medical advice.


If inhaled, remove to fresh air. If breathing is difficult, give oxygen. Seek medical attention if breathing problems continue.

Firefighting Measures Accidental Release Measures
Use water spray, foam, dry chemical, or carbon dioxide to extinguish fire. Contain the spill to prevent further release into the environment.

Handling and Storage

When handling Duloxetine, it is important to follow proper safety precautions to prevent any accidents or exposure. Here are some guidelines for handling and storage:

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  • Always wear appropriate personal protective equipment, such as gloves and safety glasses, when handling Duloxetine.
  • Avoid breathing in dust, fumes, or vapors from Duloxetine. Use adequate ventilation to prevent inhalation exposure.
  • Do not eat, drink, or smoke while handling Duloxetine.
  • Avoid contact with skin and eyes. In case of contact, rinse thoroughly with water.


  • Store Duloxetine in a cool, dry, and well-ventilated area.
  • Keep containers tightly closed when not in use to prevent contamination.
  • Avoid storing Duloxetine near incompatible materials or heat sources.
  • Keep Duloxetine away from direct sunlight and sources of ignition.

Following these handling and storage guidelines will help ensure safe usage and storage of Duloxetine.

Disposal Considerations

Disposal of Waste: Dispose of Duloxetine in accordance with all local, state, and federal regulations. Do not dispose of in household trash or down the drain.

Disposal Methods: Contact a licensed waste disposal company for proper disposal of Duloxetine. Do not incinerate the product.

Contaminated Packaging: Dispose of all contaminated packaging materials in the same manner as the product itself.

Additional Information: For specific disposal instructions, contact your local waste management authority or the Environmental Protection Agency (EPA).