Duloxetine compared to cymbalta

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Find out the key differences between duloxetine and Cymbalta to make an informed decision about your mental health treatment.

Overview of duloxetine

Duloxetine, also known by the brand name Cymbalta, is a medication primarily used to treat major depressive disorder, generalized anxiety disorder, and certain types of chronic pain conditions. It belongs to a class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs) which work by restoring the balance of certain naturally occurring substances in the brain.

Duloxetine is available in capsule form and is typically taken once daily. It is important to follow the prescribed dosage and directions provided by your healthcare provider. The medication may take several weeks to start working, so it is essential to continue taking it as directed even if you do not notice immediate improvement in your symptoms.

Common side effects of duloxetine may include nausea, dry mouth, constipation, dizziness, and headache. It is important to notify your healthcare provider if you experience any severe side effects while taking duloxetine.

Pros Cons
Effective for treating depression and anxiety May cause side effects such as nausea and dizziness
Can also help manage certain types of chronic pain May interact with other medications or substances
Available in a convenient once-daily capsule form Requires a prescription from a healthcare provider
May improve overall quality of life for individuals with these conditions May not be suitable for everyone

Comparison Overview

Cymbalta is an antidepressant medication that belongs to the class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). It is primarily used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and chronic musculoskeletal pain.

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Main Features:

Main Features:

  • Indications: Cymbalta is indicated for the treatment of various mood disorders and chronic pain conditions.
  • Mechanism of Action: Cymbalta works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood and reduce pain perception.
  • Administration: Cymbalta is available in capsule form and is typically taken orally once daily. The dosage may vary depending on the condition being treated.

Comparing Cymbalta to duloxetine: While Cymbalta is a brand name medication, duloxetine is the generic form of the drug. Both contain the same active ingredient and are used to treat similar conditions. However, there may be differences in inactive ingredients and cost between the two formulations.

Overall, Cymbalta is a commonly prescribed medication for a range of psychiatric and pain-related conditions with a proven track record of efficacy and tolerability.



When comparing Duloxetine and Cymbalta, it is essential to look at their efficacy in treating various conditions. Both medications are used to manage depression, anxiety disorders, and certain types of chronic pain. Research studies have shown that Duloxetine and Cymbalta have similar efficacy in treating these conditions.

  • Depression: Clinical trials have demonstrated that both Duloxetine and Cymbalta are effective in reducing the symptoms of depression, such as sadness, hopelessness, and loss of interest in activities.
  • Anxiety disorders: Both medications have been shown to be beneficial in managing anxiety disorders, including generalized anxiety disorder and social anxiety disorder.
  • Chronic pain: Duloxetine and Cymbalta are commonly prescribed for chronic pain conditions like fibromyalgia and neuropathic pain. Studies have indicated that both medications can help alleviate pain and improve overall functioning.
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It is important to note that individual responses to these medications may vary, and a healthcare provider should be consulted to determine the most suitable treatment option based on the specific needs of the patient.

Efficacy comparison

When comparing the efficacy of duloxetine and Cymbalta, it is important to consider their effectiveness in treating various conditions. Duloxetine is commonly used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and chronic musculoskeletal pain. On the other hand, Cymbalta is also indicated for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.

Treatment Duloxetine Cymbalta
Major Depressive Disorder ✔️ ✔️
Generalized Anxiety Disorder ✔️ ✔️
Fibromyalgia ✔️ ✔️
Chronic Musculoskeletal Pain ✔️ ✔️
Diabetic Peripheral Neuropathic Pain ✔️

Both duloxetine and Cymbalta have shown efficacy in treating these conditions, but the choice between them may depend on individual patient factors and preferences.

Side effects comparison


Duloxetine may cause side effects such as nausea, dry mouth, constipation, decreased appetite, dizziness, and fatigue. It may also lead to increased sweating, blurred vision, and sexual dysfunction. Some patients may experience insomnia, agitation, or skin reactions. It is important to consult a healthcare provider if any of these side effects occur.


Cymbalta can cause side effects including nausea, drowsiness, dry mouth, constipation, and decreased appetite. It may also result in dizziness, fatigue, blurred vision, and increased sweating. Some individuals may experience weight changes, insomnia, or sexual dysfunction. If any of these side effects persist or worsen, it is essential to seek medical attention.

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