Agomelatine vs duloxetine

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Looking for a reliable comparison between Agomelatine and duloxetine? Look no further! We’ve done the research to help you make an informed decision.

Agomelatine: This medication is known for its unique mechanism of action, targeting melatonin receptors to regulate sleep patterns and mood. It has shown effectiveness in treating depression and anxiety.

Duloxetine: On the other hand, duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that is commonly used to manage depression, anxiety, and chronic pain.

Each medication has its own benefits and potential side effects. Consult your healthcare provider to determine which option is best for you. Make an informed choice today!

Overview of Agomelatine

Agomelatine is a unique antidepressant that works by targeting both melatonin receptors and serotonin receptors in the brain. It is believed to regulate the sleep-wake cycle and mood by restoring the balance of these neurotransmitters. Agomelatine has shown efficacy in treating major depressive disorder and has a low risk of certain side effects commonly associated with other antidepressants.

Some key points about agomelatine include:

  • Targets melatonin and serotonin receptors
  • Regulates sleep-wake cycle and mood
  • Effective in treating major depressive disorder
  • Low risk of certain side effects

Overview of Agomelatine

Agomelatine is a novel antidepressant that acts as an agonist at melatonin receptors and an antagonist at serotonin receptors. It is primarily used in the treatment of major depressive disorder.

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Mechanism of Action: Agomelatine works by simultaneously modulating the circadian rhythm through melatonin receptors and improving the serotonin neurotransmission in the brain.

Benefits of Agomelatine:

  • Effective in treating depression
  • Low risk of weight gain or sexual side effects
  • May improve sleep quality

Overview of Duloxetine

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used primarily to treat major depressive disorder, generalized anxiety disorder, neuropathic pain, and fibromyalgia. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps regulate mood and alleviate pain.

Duloxetine is also approved for the treatment of stress urinary incontinence in women. It is available in delayed-release capsules that are taken orally once or twice daily. It is important to follow the prescribed dosage and not exceed the recommended dose to avoid side effects.

Common side effects of duloxetine may include nausea, dry mouth, constipation, dizziness, fatigue, and insomnia. It is important to consult with a healthcare provider before starting duloxetine to determine the appropriate dosage and monitor for any adverse reactions.

Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Consult a healthcare provider before starting any medication.

Mechanism of Action

Agomelatine and duloxetine are two different types of antidepressants with distinct mechanisms of action.


Agomelatine acts as a melatonin receptor agonist and a serotonin 5-HT2C receptor antagonist. By targeting these receptors, agomelatine helps regulate the sleep-wake cycle and mood regulation.


Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI), which increases the levels of serotonin and norepinephrine in the brain by blocking their reuptake. This helps improve mood and reduce pain signals in the brain.

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Aspect Agomelatine Duloxetine
Mechanism of Action Melatonin receptor agonist and 5-HT2C receptor antagonist Serotonin-norepinephrine reuptake inhibitor (SNRI)
Effect Regulates sleep-wake cycle and mood Increases serotonin and norepinephrine levels
Usage Primarily for depression with sleep disturbances Used for depression and chronic pain conditions

Efficacy and Side Effects

When comparing agomelatine and duloxetine, it is essential to consider their efficacy and potential side effects.



  • Agomelatine: Agomelatine has been shown to be effective in treating major depressive disorder (MDD) by targeting melatonergic and serotonergic receptors. It has demonstrated efficacy in improving mood and sleep patterns in patients with MDD.
  • Duloxetine: Duloxetine is commonly used for the treatment of MDD and has also been found to be effective in managing symptoms of anxiety disorders and chronic pain conditions.

Side Effects

  • Agomelatine: Common side effects of agomelatine may include gastrointestinal disturbances, dizziness, and headaches. It is important to monitor liver function tests during treatment with agomelatine due to rare cases of hepatotoxicity.
  • Duloxetine: Side effects of duloxetine may include nausea, dry mouth, drowsiness, and weight changes. It is crucial to monitor for changes in mood or behavior, especially in the initial stages of treatment with duloxetine.

In conclusion, both agomelatine and duloxetine have demonstrated efficacy in treating depressive disorders, but their side effect profiles may differ. It is important to work closely with a healthcare provider to determine the most suitable treatment option based on individual needs and tolerability.

Indications and Contraindications

Indications and Contraindications


Agomelatine and duloxetine are both used in the treatment of major depressive disorder (MDD). They can be prescribed for patients who experience symptoms such as persistent sadness, loss of interest or pleasure in usual activities, changes in appetite or weight, sleep disturbances, fatigue, feelings of worthlessness, or recurrent thoughts of death or suicide. These medications are often recommended when the symptoms are severe enough to interfere with daily functioning.

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Patients with a history of hypersensitivity to agomelatine or duloxetine should not take these medications. Additionally, agomelatine is not recommended for use in patients with severe hepatic impairment, as it may lead to increased exposure to the drug. Duloxetine should be used with caution in patients with a history of liver or kidney disease, as well as those with a history of alcohol abuse. Both medications may interact with other drugs or substances, so it is important to consult a healthcare provider before starting treatment.